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Akiko HONDA Akiko Honda is an assistant professor at Kyoto University. Currently, in toxicological research on elucidating the health effects and environmental chemicals. Tomoya SAGAWA Tomoya Sagawa is a researcher at Kyoto University and the Kyoto Prefectural University of Medicine. Along with his work as a clinician, he conducts research on the effects of particulate matter on cells and tissues. 26 Saheb Sharif-Askari, N., Saheb Sharif-Askari, F., Alabed, M., Temsah, M.H., Al Heialy, S., Hamid, Q. and Halwani, R. (2020) Airways expression of SARS-CoV-2 receptor, ACE2, and TMPRSS2 is lower in children than adults and increases with smoking and COPD. Molecular Therapy Methods & Clinical Development, 18: 1−6. Shao, L., Cao, Y., Jones, T., Santosh, M., Silva, L.F.O., Ge, S., da Boit, K., Feng, X., Zhang, M. and BéruBé, K. (2022). COVID-19 mortality and exposure to airborne PM2.5: A lag time correlation. The Science of the Total Environment, 806(Pt 3): 151286. Smyth, T., Veazey, J., Eliseeva, S., Chalupa, D., Elder, A. and Georas, S.N. (2020) Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin. Particle and Fibre Toxicology, 17: 52. http://doi.org/10.1186/s12989-020- 00383-x Thacker, E.L. (2006) Lung inflammatory responses. Veterinary Tsugita, M., Morimoto, N., Tashiro, M., Kinoshita, K. and Nakayama, M. (2017) SR-B1 Is a silica receptor that mediates canonical inflammasome activation. Cell Reports, 18: 1298−1311. http://doi.org/10.1016/j.celrep.2017.01.004. PMID: 28147282 Van Den Heuvel, R., Staelens, J., Koppen, G. and Schoeters, G. (2018) Toxicity of urban PM10 and relation with tracers of biomass burning. International Journal of Environmental Research and Public Health, 15: 320. http://doi.org/ 10.3390/ijerph15020320 Wang, P., Liu, H., Fan, X., Zhu, Z. and Zhu, Y. (2019) Effect of San’Xu, L., Taylor, J.E. and Kaiser, J. (2022) Short-term air pollution the United States. Yamaguchi, S.I., Xie, Q., Ito, F., Terao, K., Kato, Y., Kuroiwa, M., Omori, S., Taniura, H., Kinoshits, K., Takahashi, T., Toyokuni, S., Kasahara, K. and Nakayama, M. (2023) Carbon nanotube recognition by human Siglec-14 provokes inflammation. Nature Nanotechnology, 18: 628−636. http://doi.org/10.1038/s41565- 023-01363-w Yang, Y., Li, X., An, X., Zhang, L., Li, X., Wang, L. and Zhu, G. (2020) Continuous exacerbates ovalbumin-induced asthma in mouse lung via a JAK-STAT6 signaling pathway. Advances in Clinical and Experimental Medicine, 29: 825−832. http://doi.org/10.17219/acem/121009 Yao, Y., Pan, J.H., Liu, Z.X., Meng, X., Kan, H.D. and Wang, W. B. (2020) Temporal association between particulate matter pollution TMPRSS2 expression Research, 195: 110722. in Research, 37: 469–486. http://doi.org/10.1051/vetres:2006011 ao decoction on aggravated asthma mice model induced by PM2.5 and TRPA1/TRPV1 expressions. Journal of Ethnopharmacology, 236: 82−90. http://doi.org/10.1016/j.jep. 2019.02.043 exposure and COVID-19 Environmental Pollution, 292(Pt B): 118369. exposure the murine lung. Environmental infection in PM2.5 of A. HONDA and T. SAGAWA and case fatality rate of COVID-19 in Wuhan. Environmental Research, 189: 109941. Yasar, A., Shoukat, M., Anwar, N., Tabinda, A.B., Anwar, M.N. and Nizami, A-S. (2021) A comparison of waste recycling facilities for their contribution of heavy metals and trace elements in ambient air. Environmental Science and Pollution Research International, 28: 24807–24815. https://doi-org.kyoto-u.idm.oclc.org/10.1007/ s11356-020-12101-3 Yilin, Z., Yandong, N. and Faguang, J. (2015) Role of angiotensin-converting enzyme (ACE) and ACE2 in a rat model of smoke inhalation induced acute respiratory distress syndrome. Burns, 41: 1468−1477. Zhang, J.M. and An, J. (2007) Cytokines, inflammation, and pain. International Anesthesiology Clinics, 45: 27−37. http://doi.org/ 10.1097/AIA.0b013e 318034194e Zheng, XY., Tong, L., Shen, D., Yu, J.E., Hu, Z.Q., Li, Y.J., Zhang, L.J., Xue, E.F. and Tang, H.F. (2020) Airborne bacteria enriched PM2.5 enhances the inflammation in an allergic adolescent mouse model induced by ovalbumin. Inflammation, 43: 32−43. (Received 30 June 2023, Accepted 28 December 2023) environmental of is engaged she pollutants

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