Kazuichi HAYAKAWA Kazuichi Hayakawa graduated the Graduate School of Pharmaceutical Sciences of the University of Tokyo. He became a research assistant at Kanazawa University (1977), was promoted to professor (1996) and then dean of faculty of Pharmaceutical Sciences and director of the Institute of Nature and Environmental Technology (2012–2015). He is now a professor emeritus at Kanazawa University. He led the 21st Century Center of Excellence Program, organized by Japan’s Ministry of Education, Culture, Sports, Science and Technology (MEXT) from 2002 to 2008. He has been awarded by the Japan Society of Atmospheric Environment and others, including receiving the Commendation for Science and Technology from MEXT. His research interests are environmental pollution and the health effects of PAHs. He has published more than 400 original papers. 20 Kumagai, Y., Shinkai, Y., Miura, T. and Cho, A.K. (2012) The chemical biology of naphthoquinones and its environmental implications. Annual Review of Pharmacology and Toxicology, 52: 221–247. 134517 Li, Z., Yue, Z., Zhu, W., Liu, W., Gao, J., Zhang, J., Zhan, Z., Chen, L., Gao, H. and Wei, J. (2023) Sources, compositions, and health risks of PM2.5-bound PAHs at the rural area along with the “coal to gas” low. Aerosol and Air Quality Research, 23: 220352. McGrath, T., Chan, W. and Hajaligol, M. (2003) Low temperature aromatic mechanism hydrocarbons from the pyrolysis of cellulose. Journal of Analytical and Applied Pyrolysis, 66: 51–70. 10.1016/S0165-2370(02) 00105-5 Mordukhovichi, I., Beyea, J., Herring, A.H., Hatch, M., Stellman, S.D., Teitelbaum, D.B., Richardson, D.B., Millikan, R.C., Engel, L.S., Shantakumar, S., Steck, S.E., Neugut, A.I., Rossner, P., Jr., Santella, R. and Gammon, M.D. (2016) Vehicular traffic-related polycyclic aromatic hydrocarbon exposure and breast cancer incidence: The long island breast cancer study project (LIBCSP). Environmental Health Perspectives, 124, 30–38. 10.1289/ ehp.1307736 Motoyama, Y., Bekki, K., Chung, S.-W., Tang, N., Kameda, T., Toriba, A., Taguchi, K. and Hayakawa, K. (2009) Oxidative stress more strongly induced by ortho- than para-quinoid polycyclic aromatic hydrocarbons in A549 cells. Journal of Health Science, 55: 845–850. Orakij, W., Chetiyanukornkul, T., Chuesaard, T., Kaganoi, Y., Uozaki, W., Homma, C., Boongla, Y., Tang, N., Hayakawa, K. and Toriba, A. (2017) Personal inhalation exposure to polycyclic aromatic hydrocarbons and in rural residents in northern Thailand. Environmental Monitoring and Assessment, 189: 510. Pham, C.-T., Boongla, Y., Nghiem, T.-D., Le, H.-T., Tang, N., Toriba, A. and Hayakawa, K. (2019) Emission characteristics of polycyclic aromatic hydrocarbons and nitro-polycyclic aromatic hydrocarbons from open burning of rice straw in the north of Vietnam. International Journal of Environmental Research and Public Health, 16: 2343. Pitts, J. S., Lokensgard, D.M., Ripley, P.S., Vancauwenberghe, K.A., Vanvaeck, L., Shaffer, S.D., Thill, A.J. and Belser, W., Jr. (1980) Atmospheric epoxidation of benzo[a]pyrene by ozone-formation of the metabolite benzo[a]pyrene-4,5-oxide. Science, 210: 1347–1349. https// Pitts, J.S. (1983) Review: Formation of fate of gaseous and particulate mutagens and carcinogens in real and simulated atmospheres. Environmental Health Perspectives, 47: 115–140. Shen, H., Huang, Y., Wang, R., Zhu, D., Li, W., Shen, G., Wang, B., Zhang, Y., Chen, Y., Lu, Y., Chen, H., Li, T., Sun, K., Li, B., Liu, W., Liu, J. and Tao, S. (2013) Global atmospheric emissions of polycyclic aromatic hydrocarbons from 1960 to 2008 and future predictions. Environmental Science & Technology, 47: 6415–6424. Straif, K., Cohen, A. and Samet, J. (2013) IARC scientific publication 161 Air pollution and cancer, IARC, Lyon. ASBN 978-92-832-2166-1. Original: Park, J-H., Penning, M. (2008) Polyaromatic hydrocarbons. In: Stadler, H. and Lineback, D.R. (eds.), Process-induced Food Toxicants: Occurrence, Formation, Mitigation, and Health Risks, Chapter 2, Hoboken, Wiley. Tomaz, S., Jaffrezo, J.-L., Favez, O., Perraudin, E., Villenave, for formation of polycyclic the E. and Albinet, A. (2017) Sources and atmospheric chemistry of oxy- and nitro-PAHs in the ambient air of Gre their nitro-derivatives K. HAYAKAWA noble (France). Atmosphere Environment, 161: 144–154. Vicente, E.D. and Alves, C.A. (2018) Review: An overview of particulate emissions from residential biomass combustion. Atmospheric Research, 199: 159–185. https// j.atmosres.2017.08.027 Vondráček, J. and Machala, M. (2021) Review: The role of metabolism in toxicity of polycyclic aromatic hydrocarbons and their non-genotoxic modes of action. Current Drug Metabolism, 22: 584–593. https// 5725 Wang, S., Bai, Y., Deng, Q., Chen, Z., Dai, J., Li, X., Zhang, W., Zhang, X., He, M., Wu, T. and Guo, H. (2016) Polycyclic aromatic hydrocarbons exposure and lung function decline among coke-oven workers: A four-year follow-up study. Environmental Research, 150: 14–22. j.envres.2016.05.025 WHO (2018) Air Pollution and child health: Prescribing clean air. Retrieved (accessed 29 October 2018) WHO (2023) Air Pollution. Retrieved from: health-topics/air-pollution#tab=tab_1 (accessed 28 August 2023) Yoshikawa, T., Ruhr, L.P., Flory, W., Giamalva, D., Church, D.F. and Pryor, W.A. (1985) Toxicity of polycyclic aromatic hydrocarbons. 1. Effect of phenanthrene, pyrene, and their ozonized products on blood chemistry in rats. Toxicology and Applied Pharmacology, 79: 218–226. Zhang, Y., Shen, Z., Sun, J., Zhang, L., Zhang, B., Zou, H., Zhang, T., Ho, S. S. H., Chang, X., Xu, H., Wang, T., Cao, J. (2021) Parent, alkylated, oxygenated and nitrated polycyclic aromatic hydrocarbons in PM2.5 emitted from residential biomass burning and coal combustion: A novel database of 14 heating scenarios. Environmental Pollution, 268, 115881. j.envpol.2020.115881. Zhao, J.Y., Hara, A., Hayakawa, K., Pham, K.O., Suzuki, K., Tsujiguchi, H., Matsuzaki, H., Odajima, H., Takami, A. and Nakamura, H. (2022) Longitudinal study on the association between ambient polycyclic aromatic hydrocarbons and nasal symptoms in adult Japanese. Applied Sciences, 12: 12544. https// (Received 28 August 2023, Accepted 22 December 2023) from: https// from

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